A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.
نویسندگان
چکیده
MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).
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عنوان ژورنال:
- The Biochemical journal
دوره 446 1 شماره
صفحات -
تاریخ انتشار 2012